CHAPTER 22 - Fungal Ribosome Inactivating Proteins

Add time:09/24/2019    Source:sciencedirect.com

ABSTRACTRibosome inactivating proteins (RIPs) have been isolated from a number of fungi including Aspergillus and Trichoderma spp. and several mushrooms. Ribosome inactivating peptides found in Cucurbitaceous seeds have not been detected in fungi. The smallest fungal RIP isolated to date, velutin—from the mushroom (basidiomycete fungus) Flammulina velutipes—has a molecular mass of about 14 kDa. Small RIPs with a molecular mass of approximately 20 kDa, and RIPs about 30 kDa in molecular mass, are found in both fungal and plant RIPs. The Aspergillus RIPs are ribonucleases with high-sequence homology. In contrast, most mushroom RIPs do not show structural resemblance to each other and have little or no ribonuclease activity. All fungal RIPs demonstrate potent inhibitory activity in the cell-free translation system. Other activities of fungal RIPs include mitogenic/antimitogenic activity toward splenocytes and antiproliferative activity toward tumor cells. RIPs probably serve a role of defense in fungi.

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