Convenient synthesis of arylpropargyl aldehydes and 4-aryl-3-Butyn-2-one (cas 1423-60-5)s from arylacetylenes and amide acetals

Add time:09/28/2019    Source:sciencedirect.com

The reaction of arylacetylenes 1 and N,N-dimethylformamide dimethylacetal (2a, DMF-DMA) afforded the corresponding arylpropargyl aldehydes 3 in moderate yields. Similarly, the reaction of 1 and N,N-dimethylacetamide dimethylacetal (2b, DMA-DMA) gave 4-aryl-3-butyn-2-ones 4.

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