Welcome to LookChem.com Sign In | Join Free

Science Details

Home > Chemical Encyclopedia > Science List > Details
  • Biotransformation of androgenic steroid Mesterolone (cas 1424-00-6) with Cunninghamella blakesleeana and Macrophomina phaseolina

  • Add time:09/27/2019    Source:sciencedirect.com

    Fermentation of Mesterolone (cas 1424-00-6) (1) with Cunninghamella blakesleeana yielded four new metabolites, 1α-methyl-1β,11β,17β-trihydroxy-5α-androstan-3-one (2), 1α-methyl-7α,11β,17β-trihydroxy-5α-androstan-3-one (3), 1α-methyl-1β,6α,17β-trihydroxy-5α-androstan-3-one (4) and 1α-methyl-1β,11α,17β-trihydroxy-5α-androstan-3-one (5), along with three known metabolites, 1α-methyl-11α,17β-dihydroxy-5α-androstan-3-one (6), 1α-methyl-6α,17β-dihydroxy-5α-androstan-3-one (7) and 1α-methyl-7α,17β-dihydroxy-5α-androstan-3-one (8). Biotransformation of 1 with Macrophomina phaseolina also yielded a new metabolite, 1α-methyl, 17β-hydroxy-5α-androstan-3,6-dione (9). The isolated metabolites were subjected to various in vitro biological assays, such as anti-cancer, inhibition of α-glucosidase, and phosphodiesterase-5 enzymes and oxidative brust. However, no significant results were observed. This is the first report of biotransformation of 1 with C. blakesleeana and M. phaseolina.

    We also recommend Trading Suppliers and Manufacturers of Mesterolone (cas 1424-00-6). Pls Click Website Link as below: cas 1424-00-6 suppliers

    Prev:Metabolic studies of Mesterolone (cas 1424-00-6) in horses
    Next:Mesterolone (cas 1424-00-6))

  • Back】【Close 】【Print】【Add to favorite
Periodic Table
    Related Products