Methyl 3-phenylsulfonyl orthopropionate: A new reagent for cyclopentannulation
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Add time:10/01/2019 Source:sciencedirect.com
The title compound 1 is readily prepared by a Pinner reaction on the adduct of phenylsulfinic acid with acrylonitrile. The anion derived from 1 adds 1,4 to enones to give specific enolates which are trapped with trimethylsilyl chloride. The resulting trimethylsilyl enol ethers cyclise smoothly to give cyclopentannulated products in good yields.
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