Review1,1,2,2-Tetrafluoroethyl-N,N-dimethylamine: a new selective fluorinating agent☆

Add time:09/26/2019    Source:sciencedirect.com

The title compound has been prepared in 96–98% yield by the reaction of tetrafluoroethylene and dimethylamine. 1,1,2,2-Tetrafluoroethyl-N,N-dimethylamine (1) is found to be an effective reagent for the conversion of alcohols into alkyl fluorides. Reaction of 1 and primary alcohols proceeds with high yield formation of the corresponding alkyl fluorides at elevated temperature. However, the reaction of secondary and tertiary alcohols rapidly takes place at 0–10°C, producing corresponding alkyl fluorides as major product along with some olefins.

We also recommend Trading Suppliers and Manufacturers of ALLYL 1,1,2,2-TETRAFLUOROETHYL ETHER (cas 1428-33-7). Pls Click Website Link as below: cas 1428-33-7 suppliers

Prev:Copper(0)-mediated fluoroalkylation of iodobenzene with 2-bromo-1,1,2,2-tetrafluoroethyl compounds: Investigation on the influence of R substituent on the reactivity of RCF2Cu species
Next:Development of (2-bromo-1,1,2,2-tetrafluoroethyl)(phenyl)sulfane as tetrafluoroethyl-radical and tetrafluoroethylene-diradical synthons for additions to alkenes)