Synthesis and biological evaluation of the disulfide form of the glutathione analogue γ-(l-glutamyl)-l-cysteinyl-l-aspartyl-l-cysteine

Add time:09/30/2019    Source:sciencedirect.com

By using the chain to chain mode of cyclization the title glutathione analogue (4), containing the 11-membered disulfide ring replacing the native -Cys-Gly fragment, has been synthesized and characterized together with its reduced dithiol form γ-Glu-Cys-Asp-Cys (5). The activity of (4) with γ-glutamyl-transferase and glutathione reductase has been evaluated and compared with those of the two conformationally restricted glutathione analogues (2) and (3) previously reported.

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