Concise synthesis of (+)-conduritol F and inositol analogues from naturally available (+)-proto-quercitol (cas 17278-12-5) and their glucosidase inhibitory activity

Add time:10/01/2019    Source:infona.pl

An effective synthesis of (+)-conduritol F, (+)-chiro- and (+)-epi-inositols from naturally available (+)-proto-quercitol is described. This synthetic method provides a concise synthesis of cyclitols in enantiomerically pure form. Of the synthesized cyclitols, (+)-conduritol F potently inhibits type I α-glucosidase with an IC 50 value of 86.1μM, which is five times greater than the standard antidiabetic drug, acarbose.

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