Vitamin K3 and K5 are inhibitors of tumor pyruvate kinase M2

Add time:09/26/2019    Source:infona.pl

Pyruvate kinase M2 (PKM2) is a rate-limiting enzyme of aerobic glycolysis in cancer cells and plays important roles in cancer metabolism and growth. Here we show that vitamin K 3 and K 5 (VK 3 and VK 5 ) are relatively specific PKM2 inhibitors. VK 3 and VK 5 showed a significantly stronger potency to inhibit PKM2 than to inhibit PKM1 and PKL, 2 other isoforms of PK dominantly expressed in most adult tissues and liver. This study combined with previous reports supports that VK 3 and VK 5 have potential as adjuvant for cancer chemotherapy.

We also recommend Trading Suppliers and Manufacturers of VITAMIN K5 (cas 130-24-5). Pls Click Website Link as below: cas 130-24-5 suppliers

Prev:Effects of vitamin K3 and K5 on proliferation, cytokine production, and regulatory T cell-frequency in human peripheral-blood mononuclear cells
Next:In vitro Growth Inhibition of Food-borne Pathogens and Food Spoilage Microorganism by VITAMIN K5 (cas 130-24-5))