In‐vitro antimicrobial, thermal and spectral studies of mixed ligand Cu(II) heterochelates of Clioquinol (cas 130-26-7) and coumarin derivatives

Add time:09/26/2019    Source:infona.pl

The mixed‐ligand heterochelates of Cu(II) with 5‐chloro‐7‐iodo‐8‐hydroxyquinoline (Clioquinol (cas 130-26-7)) and various uninegative bidentate ligands were prepared. The structure of mixed‐ligand heterochelates was investigated using spectral, physicochemical, elemental analysis and thermal studies. The FAB‐mass spectrum of [Cu(A2)(CQ)(H2O)2].2H2O has been carried out. Magnetic moment and reflectance spectral studies reveal that an octahedral geometry has been assigned to all the prepared heterochelates. The kinetic parameters such as order of reaction (n), the energy of activation (Ea), the pre‐exponential factor (A), the activation entropy (ΔS#), the activation enthalpy (ΔH#) and the free energy of activation (ΔG#) have been reported. The ligands, metal salts, heterochelates, control and standard drug were tested for their in‐vitro antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, Serratia marcescens and Bacillus substilis. The metal complexes exhibit good activity against bacterial strains compared with parental compounds, and moderate compared with the standard drug (clioquinol). Copyright © 2010 John Wiley & Sons, Ltd.

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