Novel C-nucleoside analogs of 1,3-dioxolane: Synthesis of enantiomeric (2′R,4′S)- and (2′S,4′R)-2-[4-(hydroxymethyl)-1,3-dioxolan-2-yl]-1,3-thiazol-4-carboxamide

Add time:07/15/2019    Source:sciencedirect.com

Novel C-nucleosides (2′R,4′S)-and (2′S,4′R)-2-[4-(hydroxymethyl)-1,3-dioxolan-2-yl]-1,3-thiazole-4-carboxamide have been synthesized from stereoselectively induced condensation of optically active triols (S or R) with a 1,3-thiazole-4-carboxamide derivative.

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