Protective effects of the polyphenols (+)-EPISESAMIN (cas 133-03-9) and sesamin against PDGF-BB-induced activation of vascular smooth muscle cells are mediated by induction of haem oxygenase-1 and inhibition of mitogenic signalling

Add time:09/30/2019    Source:infona.pl

Activation of vascular smooth muscle cells (VSMCs) represents a key event of atherosclerosis. It is triggered e.g. by the action of platelet-derived growth factor (PDGF). The polyphenol (+)-episesamin (ES) is known to block the TNF-α-induced mitogenic VSMC response. Aiming to develop novel therapeutic options e.g. by dietary supplements, we studied if ES and its stereoisomer sesamin (SE) reduce PDGF-BB-induced growth and migration, which both promote atherosclerosis. ES and SE reduced basal and PDGF-BB-induced proliferation and migration of human, murine and rat VSMC by impaired activation of MAPK and PI3K pathways and reduced oxidative stress by induction of haem oxygenase-1 expression. Moreover, ES and SE blocked PDGF-BB-induced activation of NF-κB with subsequently reduced expression and secretion of the gelatinases matrix-metalloproteinase-(MMP)-2 and MMP-9. In conjunction with their natural origin and well-tolerable properties, these data suggest ES and SE as potential candidates for a complemental treatment of VSMC specific vascular diseases like atherosclerosis.

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Prev:The lignan (+)‐EPISESAMIN (cas 133-03-9) interferes with TNF‐α‐induced activation of VSMC via diminished activation of NF‐ĸB, ERK1/2 and AKT and decreased activity of gelatinases
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