10-(2-Benzoxazolcarbonyl)-5,10-dideaza-acyclic-5,6,7,8-TETRAHYDROFOLIC ACID (cas 135-16-0) - A potential inhibitor of GAR transformylase and AICAR transformylase

Add time:09/30/2019    Source:infona.pl

The design and synthesis of 10-(2-benzoxazolcarbonyl)-DDACTHF (1) as an inhibitor of glycinamide ribonucleotide transformylase (GAR Tfase) and aminoimidazole carboxamide transformylase (AICAR Tfase) are reported. Ketone 1 and the corresponding alcohol 13 were evaluated for inhibition of GAR Tfase and AICAR Tfase and the former was found to be a potent inhibitor of recombinant human (rh) GAR Tfase (K i =600 nM).

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