Fuctionalization of Linear and Angular Phenothiazine and Phenoxazine (cas 135-67-1) Ring Systems via Pd(0)/XPhos Mediated Suzuki‐Miyaura Cross‐coupling Reactions

Add time:10/01/2019    Source:infona.pl

Chloro‐substituted phenothiazines and Phenoxazine (cas 135-67-1)s were successfully derivatized with phenylboronic and styrylboronic acids using Suzuki–Miyaura cross‐coupling reaction catalyzed by Pd(0)/XPhos for the first time in good yields. The protocol employed 4 mol% Pd and 7 mol% XPhos with K3PO4 in acetonitrile at 80°C. The reaction condition is compatible with carbonyl and unprotected N–H groups in substrates. Structural assignments were established by combined spectroscopic (UV, IR, 1H, and 13C NMR), MS, and elemental analytical data.

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