Facile entries for regioselective synthesis of [1,2,4]triazolo-[4,3-a]pyrimidin-5(1H)-ones from 2-Thiouracil (cas 141-90-2)

Add time:09/30/2019    Source:infona.pl

Three new alternative synthetic strategies based on reactions of hydrazonoyl halides 3 with 2-methylthiouracil 2 and treatment of either 2-pyrimidinyl thiohydrazonates 8 or the diazonium coupling products of active (pyrimidin-2-ylthio)methylene compounds 12 with sodium ethoxide in ethanol are described for the title compounds. The mechanisms and regiochemistry of the studied reactions are discussed.

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