Nucleophilic fluoroalkylation of (bromomethyl)pinacolborane using silicon reagents

Add time:07/15/2019    Source:sciencedirect.com

A method for the synthesis of pinacol boronic esters bearing a fluorinated group at the α-carbon atom (RfCH2Bpin) from corresponding bromomethyl borane (BrCH2Bpin) and fluorinated silanes (RfSiMe3) is described. The fluoroalkylation reaction involves formation of borate anions followed by intramolecular nucleophilic substitution of bromine.

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