Synthesis and biological evaluation of 2-Hydroxy derivatives of DIGITOXIGENIN (cas 143-62-4) and 3-EpiDIGITOXIGENIN (cas 143-62-4)1A preliminary account of this work has been presented at the First International Electronic Conference on Synthetic Organic Chemistry (ECSOC-1), A0012, 1–30 September 1997; http://www.mdpi.org/escoc-1.htm1

Add time:09/30/2019    Source:infona.pl

The four stereoisomers of the 2-hydroxy derivatives of DIGITOXIGENIN (cas 143-62-4) and 3-epidigitoxigenin have been synthesized, their structures established by NMR, and their binding affinity for the digitalis receptor on Na+, K+-ATPase evaluated. These derivatives showed lower affinities than the parent compounds. The hydrophilic hydroxy groups in the alpha position are more detrimental to the affinity than hydroxy groups in the beta position.

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