Quantitative analysis of Diphenhydramine Hydrochloride (cas 147-24-0) in pharmaceutical wafers using near infrared and Raman spectroscopy

Add time:09/30/2019    Source:infona.pl

Wafers with varying concentrations of Diphenhydramine Hydrochloride (cas 147-24-0) (DPH-HCl) as active pharmaceutical ingredient (API) were prepared and their near infrared (NIR) and Raman spectra recorded. The purpose of this study was to compare the suitability of these two vibrational spectroscopic techniques for the quantification of DPH-HCl in pharmaceutical wafers. Partial least squares (PLS1) calibration models with different data pretreatments were tested. Both NIR and Raman spectroscopy proved to be suitable to predict DPH-HCl contents at lower concentration ranges. At higher concentrations, interference by crystallization processes was observed. For investigating the general applicability of the quantification methods, two commercially available products were examined.

We also recommend Trading Suppliers and Manufacturers of Diphenhydramine Hydrochloride (cas 147-24-0). Pls Click Website Link as below: cas 147-24-0 suppliers

Prev:Comparison Between the Effect of Strongly and Weakly Cationic Exchange Resins on Matrix Physical Properties and the Controlled Release of Diphenhydramine Hydrochloride (cas 147-24-0) from Matrices
Next:Synthesis and Crystal Structures of Methyl 3,4,5-Trimethoxybenzoate and 1,2-Dihydro-2,2,4-trimethylquinoline (cas 147-47-7) Derivatives)