Direct on-column derivatisation in gas chromatography III. On-column benzylation reagents and the development of 3,5-bis(trifluoromethyl)benzyl-dimethylphenylammonium fluoride, an efficient new on-column derivatisation reagent

Add time:07/15/2019    Source:sciencedirect.com

Direct on-column methylation using methylammonium or sulfonium salts is well established. It has now been demonstrated that benzylammonium salts are effective derivatisation reagents for direct on-column benzylations of acids and phenols. They are particularly useful for the derivatisation of lower aliphatic acids where methyl derivatives are too volatile for convenient GC determination and for simple phenols were reagent by-products from on-column methylation interfere with determination of cresols. 3,5-Bis(trifluoromethyl)benzyldimethylphenylammonium fluoride is a readily prepared and highly efficient new reagent for direct on-column derivatisation in GC and GC-MS. It produces derivatives with phenols which are not only easily detected by GC with electron-capture detection but which also give a total ion current 1.5–3 times higher than the corresponding methyl derivatives in the GC-MS of phenols and acids.

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