RONGALITE (cas 149-44-0)® promoted highly regioselective synthesis of β-hydroxy sulfides by ring opening of epoxides with disulfides

Add time:09/30/2019    Source:infona.pl

Rongalite® promotes cleavage of disulfides generating thiolate anions that then undergo facile ring opening of epoxides in the presence of K2CO3 to afford α-addition products 3 with good to excellent yields. The important features of this methodology are broad substrates scope, high yielding, reasonably rapid reaction rate, high regioselectivity and no requirement of metal catalysts. It should be noted that the thiolate anion attacks the epoxides derived from styrene to produce the corresponding α-addition products 3 with high regioselectivity, instead of the β-addition regioisomer 4 that could be formed from the attack of the nucleophile at the benzylic position.

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