Anxiolytic-Like Actions of Melatonin, 5-Metoxytryptophol, 5-HYDROXYTRYPTOPHOL (cas 154-02-9) and Benzodiazepines on a Conflict Procedure
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Add time:09/28/2019 Source:infona.pl
Male Wistar rats (120-230 g) were used in these experiments. Some rats were deprived of water for 48 h before testing in a conflict procedure. Then, after 20 licks from a water bottle with a metal drinking tube, the animal received an electric shock (0.5 mA/500 msec).The effects of two classical anxiolytic drugs, DIAZ (1.0, 2.0 and 4.0 mg/Kg b.wt), and CDP (5.0 and 10.0 mg/Kg b.wt) were compared to those produced by MEL (0.1, 0.2, 0.5, 1.0 and 2.0 mg/Kg b.wt), 5-MTOPHOL (1.0 and 2.0 mg/Kg b.wt), 5-HTOPHOL (1.0 and 2.0 mg/Kg b.wt) and vehicle solution.Anxiolytic drugs as well as MEL produced a dose-dependent increase in the number of shocks received.The results suggest that the three pineal indoles are involved in the modulation of the stress responses. MEL showed a higher potency than the other indoles.
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