Enantio-complementary deracemization of (±)-2-hydroxy-4-phenylbutanoic acid and (±)-3-phenyllactic acid (cas 156-05-8) using lipase-catalyzed kinetic resolution combined with biocatalytic racemization

Add time:09/28/2019    Source:infona.pl

Deracemization of (±)-3-phenyllactic acid (1) and (±)-2-hydroxy-4-phenylbutanoic acid (2) was accomplished by lipase-catalysed kinetic resolution coupled to biocatalytic racemization of the non-reacting substrate enantiomers using Lactobacillus paracasei DSM 20008. Cyclic repetition of this sequence led to a single enantiomeric product from the racemate. Access to both enantiomers was achieved by switching between lipase-catalysed acyl-transfer and ester hydrolysis reactions. Both products constitute important building blocks for virus protease- and ACE-inhibitors, respectively.

We also recommend Trading Suppliers and Manufacturers of 3-phenyllactic acid (cas 156-05-8). Pls Click Website Link as below: cas 156-05-8 suppliers

Prev:Myasthenia gravis requiring PYRIDOSTIGMINE (cas 155-97-5) treatment in a national population cohort
Next:Effects of NADH Availability on 3-phenyllactic acid (cas 156-05-8) Production by Lactobacillus plantarum Expressing Formate Dehydrogenase)