Regioselective and Stereoselective Reductive Cleavage of 1,7-Dioxaspiro[5.5]undecane Alcohols

Add time:09/28/2019    Source:infona.pl

Lewis acid-promoted triethylsilane reduction of 6,6-spiroketal alcohols produces cis-2,6-disubstituted tetrahydropyrans with excellent regioselectivity and stereocontrol. An appended alcohol allows bidentate coordination of the Lewis acid to selectively activate one C-O bond of the anomeric center toward reductive cleavage.

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