Mechanistic Study of a Complementary Reaction System that Easily Affords Quinazoline and perimidine (cas 204-02-4) Derivatives
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Add time:09/29/2019 Source:infona.pl
A new reaction between 2‐aminobenzophenone and thiourea in dimethyl sulfoxide (DMSO) has been developed that primarily affords 4‐phenylquinazoline as a single product. This reaction is also applicable, in general, to the reactions between thiourea and conformation‐restricted β‐amino ketones, such as 1‐aminoanthracene‐9,10‐dione and 1‐amino‐9H‐fluoren‐9‐one, to prepare perimidine (cas 204-02-4) derivatives. Experimental data is consistent with our computational study on the thermal decomposition of thiourea to form hydrogen sulfide and carbodiimide. This reaction involves a coupling between 2‐aminobenzophenone and carbodiimide generated in situ from thiourea to form 4‐phenylquinazolin‐2(1H)‐imine intermediate, and the generation of sulfur‐containing reducing agent from hydrogen sulfide and DMSO, which reduces 4‐phenylquinazolin‐2(1H)‐imine to 4‐phenyl‐1,2‐dihydroquinazolin‐2‐amine. Elimination of ammonia from the latter yields 4‐phenylquinazoline.
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- Vinylphosphonium salt mediated simple synthesis of 7-oxo-7H-pyrido[1,2,3-cd]perimidine (cas 204-02-4) derivatives. Dynamic NMR spectroscopic study of prototropic tautomerism in ethyl 1H-perimidine (cas 204-02-4)-2-carboxylate09/30/2019
- Syntheses, Physico‐Chemical Studies and Antioxidant Activities of Transition Metal Complexes with a perimidine (cas 204-02-4) Ligand09/28/2019