The utilization of anhydrovitamin A (cas 1224-78-8) by the vitamin A-deficient rat

Add time:07/12/2019    Source:sciencedirect.com

anhydrovitamin A (cas 1224-78-8) was fed to vitamin A-deficient rats and its metabolites isolated from the livers. These consisted of two monohydroxy and one dihydroxy derivatives and their esters. None was identical with retro-vitamin A prepared chemically from vitamin A. Neither anhydrovitamin A nor its derivatives gave rise to any detectable amount of vitamin A in the liver; nor was anhydrovitamin A present as such in the liver. Similar results were obtained after subcutaneous injection of a water dispersion of anhydrovitamin A. Two compounds similar to those isolated from the liver also were found in the kidneys. The results suggested that (a) anhydrovitamin A whether fed orally or injected subcutaneously was not absorbed and stored to any measurable extent by the rat, (b) hydroxylation mechanisms were involved in the utilization of anhydrovitamin A and (c) the growth-promoting activity of anhydrovitamin A was due to one or more of its derivatives formed in vivo.

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