Structural requirement of TUNICAMYCIN (cas 11089-65-9) V for MraY inhibition
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Add time:07/16/2019 Source:sciencedirect.com
Elucidating a structure-activity relationship study by evaluating a series of truncated analogues is a simple but important and effective tactic in medicinal chemistry based on natural products with a large and complex chemical structure. In this study, a series of truncated analogues of TUNICAMYCIN (cas 11089-65-9) V were designed and synthesized and their MraY inhibitory activity was investigated in order to gain insight into the effect of these moieties on MraY inhibition.
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