1H and 13C NMR and X-ray studies of 2- and 4-phenyl-6,7-dimethoxy-3methyl-3,4-dihydro-2H-1,3-benzothiazines [1]

Add time:07/15/2019    Source:sciencedirect.com

The stereochemistry of 2- and 4-phenyl-6,7-dimethoxy-3-methyl-3,4-dihydro-2H-1,3-benzothiazine (2,6) has been studied by 1H, 13C NMR spectroscopy and X-ray diffraction. Crystals of compound 2 (C17H19NO2S) are monoclinic, space group P21/n, with a = 11.428(1), b = 10.048(1), c = 14.161(2) Å, ß = 100.00(1)°, Z = 4, Dc = 1.247 g cm−3. Crystals of 6 are orthorhombic, space group P212121 with a = 7.068(1), b = 10.857(1), c = 20.343(1) Å, Z = 4, Dc = 1.247 g cm−3. The structures are refined to R = 0.041 for 2728 reflections of 2 and R = 0.039 for 1671 reflections of 6. The results unequivocally show that the 3-N-methyl group, and the 4-phenyl group are axial, while the 2-phenyl moiety is equatorial. Comparison are made between conformations of the title compounds and those of the following 1-phenyltetrahydroisoquinolines: unnatural cryptostyline II [2, 3], crypstostyline I [4] and 2-benzyl-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-phenyl-isoquinolinium iodide [5].

We also recommend Trading Suppliers and Manufacturers of [4-(3,4-DIMETHOXY-PHENYL)-THIAZOL-2-YL]-ACETONITRILE (cas 380348-77-6). Pls Click Website Link as below: cas 380348-77-6 suppliers

Prev:(±)α-Phenyl-β-(3,4-dimethoxy)- and (±)α-Phenyl-β-(3,4-dihydroxy)phenethylamines: Potential Probes for Nicotinic Acetylcholine Receptor-Ion Channel Molecule from Torpedo Electric Organ
Next:Tricarbonylchromium(0) promoted stereoselective cyclisations of the N-3,4-dimethoxyphenethyl derivatives of the 1-phenyl ethanolamines halostachine, ephedrine and pseudoephedrine to 1-phenyl-N-methyl-7,8-dimethoxy-1,2,4,5-tetrahydrobenzazepines)