A highly dispersed multi-walled carbon nanotubes and poly(methyl orange) based electrochemical sensor for the determination of an anti-malarial drug: Amodiaquine

Add time:07/18/2019    Source:sciencedirect.com

A glassy carbon electrode modified with electrochemically polymerized methyl orange (PMO) and multi-walled carbon nanotubes (MWCNT) was developed. The morphologies of the fabricating materials (PMO and MWCNT) were investigated by field-emission scanning electron microscopy (FE-SEM). The designed sensor was used for the sensitive determination of amodiaquine (AQ), an anti-malaria drug. AQ was developed as an alternative to chloroquine because of its activity against chloroquine-resistant Plasmodium falciparum (P. falciparum) parasites. The modified electrode was employed to study the electrochemical oxidation of AQ using cyclic voltammetry (CV) and differential pulse voltammetry (DPV) techniques. Under optimal experimental conditions, DPV exhibited a linear response in the concentration range from 1.0 × 10−7 to 3.5 × 10−6 mol L−1 with a limit of detection (LOD) of 8.9 × 10−8 mol L−1. Furthermore, the number of electrons and protons involved in the electrochemical study of AQ was also calculated and a plausible mechanism for the electro-oxidation of AQ was deduced. The developed sensor demonstrated analytical applicability as it was successfully employed to determine the drug AQ in pharmaceutical formulations and human urine samples.

We also recommend Trading Suppliers and Manufacturers of Disperse Orange 20 (cas 11100-24-6). Pls Click Website Link as below: cas 11100-24-6 suppliers

Prev:Nonlinear optical characterization of Disperse Orange 3
Next:Absorption cross-sections of Disperse Orange 13 and Irgacure 784 determined with mask projection vat photopolymerization)