High-performance liquid chromatographic enantioseparation of β2-amino acids using a long-tethered (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid-based chiral stationary phase

Add time:07/17/2019    Source:sciencedirect.com

Reversed-phase high-performance liquid chromatographic methods were developed for the separation of enantiomers of eleven unnatural β2-amino acids on a new chiral stationary phase, using the 11-methylene-unit spacer of aminoundecylsilica gel for the bonding of (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid as selector. The nature and concentration of the acidic and organic modifiers, the pH, the mobile phase composition, and the structures of the analytes substantially influenced the retention and resolution. Separations were carried out at constant mobile phase compositions in the temperature range 7–40 °C and the changes in enthalpy, Δ(ΔH°), entropy, Δ(ΔS°), and free energy, Δ(ΔG°) were calculated. The elution sequence was determined in some cases: the S enantiomers eluted before the R enantiomers.

We also recommend Trading Suppliers and Manufacturers of 2-Benzylpropionic acid (cas 1009-67-2). Pls Click Website Link as below: cas 1009-67-2 suppliers

Prev:Synthesis of chiral building blocks for selective adenosine receptor agents. Lipase-catalyzed resolution of 2-benzylpropanol and 2-Benzylpropionic acid (cas 1009-67-2).
Next:Distance-dependent capture probability of male Mediterranean fruit flies in TRIMEDLURE (cas 1009-74-1)-baited traps in Hawaii)