Molecular mechanism underlying the ability of caffeic acid to decrease uric acid levels in hyperuricemia rats

Add time:07/16/2019    Source:sciencedirect.com

The mechanism underlying the reduction in uric acid levels in hyperuricemia rats by caffeic acid was investigated in this study. Different doses of caffeic acid (25, 50, and 100 mg/kg) were administered to hyperuricemia rats induced by the intraperitoneal injection of potassium oxonate. In vivo study showed that caffeic acid can down-regulate the transcription levels of URAT1 and GLUT9 mRNA and up-regulate the transcription levels of OAT1, UAT, and ABCG2 mRNA. In vitro study indicated caffeic acid competitively binds with xanthine oxidase to inhibit its activity, and the IC50 value was 53.45 µM. It was concluded that caffeic acid decreases serum uric acid levels in hyperuricemia rats by binding with xanthine oxidase and inhibiting its catalytic activity and by regulating the mRNA transcription of the renal uric acid transporters.

We also recommend Trading Suppliers and Manufacturers of URIC ACID SODIUM SALT (cas 1198-77-2). Pls Click Website Link as below: cas 1198-77-2 suppliers

Prev:Design, synthesis and antifungal activities of novel pyrrole alkaloid analogs
Next:Opposing effects of sodium intake on uric acid and blood pressure and their causal implication)