Fluorination of aromatic α-hydroxyesters with N,N-diethyl-1,1,2,3,3,3-hexafluoropropaneamine

Add time:07/12/2019    Source:sciencedirect.com

The reaction of N,N-diethyl-1,1,2,3,3,3-hexafluoropropaneamine(PPDA) with aromatic α-hydroxyesters exchanged F for OH and gave their corresponding fluorides. For example, ethyl 2-fluoro-2-(p-tolyl) acetate was obtained from the reaction of ethyl 2-hydroxy-2-(p-tolyl) acetate with PPDA.

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