Analgesic and Anti-Inflammatory Evaluation of Thymotic Acid and Certain Homologs

Add time:07/19/2019    Source:sciencedirect.com

Ortho-thymotic acid and nine homologs were submitted for general, analgesic, and antistress evaluations in the rat. While all appeared to be nonspecific central nervous system depressants, only 2-methyl-5-tert-butylsalicylic acid appeared to have significant analgesic ability in the rat tail flick test. 2-Hydroxy-4-methyl-5-isopropylbenzoic acid, 2-hydroxy-4-isopropyl-6-methylbenzoic acid, and 2-hydroxy-3-methyl-6-isopropylbenzoic aicd were superior to sodium salicylate and inferior to morphine sulfate in providing significant protection from stress induced by unilateral hind leg tourniquets. The latter two compounds were active in suppressing the acute inflammatory process produced by pedal injection of carrageenin, but were ineffective against chronic inflammation induced by the Mycobacterium butyricum adjuvant.

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