Effects of phenylated compounds of methylglyoxal bis(guanylhydrazone) on diamine oxidase activity from rat small intestine

Add time:07/16/2019    Source:sciencedirect.com

1. Two phenylated compounds of methylglyoxal bis(guanylhydrazone), potentially inhibitors of diamine oxidase activiy, have been synthesized: phenylglyoxal bis(guanylhydrazone) and diphenyl-glyoxal bis(guanylhydrazone).2. Their inhibitory capacity was tested: while PGBG was able to reduce the enzyme activity by 50% at 1.3 μM, DPGBG was only able to reduce diamine oxidase activity by less than 2% at a concentration 1000-fold higher.3. The inhibition of PGBG was non-competitive and the Ki calculated by a Dixon plot was estimated as 1.7 μM.

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