Diastereoselective synthesis of Pro-Phe phosphinyl dipeptide isosteres

Add time:07/12/2019    Source:sciencedirect.com

The diastereoselective synthesis of Pro-Phe phosphinyl dipeptide isosteres in protected form was achieved by starting from optically active 1,1-diethoxyethyl(aminomethyl)phosphinate. Our methodology involves diastereoselective α-alkylation and β′-alkylation of phosphinate derivatives with an asymmetric center at the phosphorus atom.

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