Cinchona alkaloid derived squaramide catalyzed diastereo- and enantioselective Michael addition of isocyanoacetates to 2-enoylpyridines

Add time:07/17/2019    Source:sciencedirect.com

An efficient organocatalytic diastereo- and enantioselective Michael addition of α-substituted isocyanoacetates to 2-enoylpyridines catalyzed by cinchona alkaloid-derived squaramide has been achieved, affording the corresponding adducts with two adjacent tertiary-quaternary stereocenters in excellent yields (up to 99%) and good to excellent stereoselectivities (up to >20:1 dr, up to 98% ee) under mild conditions.

We also recommend Trading Suppliers and Manufacturers of Methyl-4-oxo-4-phenyl-2-butenoate (cas 14274-07-8). Pls Click Website Link as below: cas 14274-07-8 suppliers

Prev:Asymmetric Friedel–Crafts alkylation of activated benzenes with methyl (E)-2-oxo-4-aryl-3-butenoates catalyzed by [Pybox/Sc(OTf)3]
Next:Absorption spectral change of peripheral-light harvesting complexes 2 induced by magnesium protoporphyrin (cas 14947-11-6) IX monomethyl ester association)