Synthesis and application of a novel asymmetric azo reagent: 1-(tert-butyl)-2-(4-chlorobenzyl) azodicarboxylate (tBCAD)

Add time:07/11/2019    Source:sciencedirect.com

A series of novel asymmetric azo reagents, 1-(tert-butyl)-2-(4-substituted benzyl) azodicarboxylate, were prepared. The synthetic process has the advantage of simpleness, easy operation, mild reaction condition and high yield. The 1-(tert-butyl)-2-(4-chlorobenzyl) azodicarboxylate (tBCAD) was selected for its stability and convenience to handle, and its precursor can be recycled by recrystallization with toluene. The tBCAD and DIAD were applied to a wide variety of Mitsunobu reactions. The experimental results showed that the performance of tBCAD in Mitsunobu reaction was comparable to that of DIAD, while the stability of tBCAD was much better than DIAD. Thus, tBCAD can be a novel, stable, effective azo-reagent for the Mitsunobu reaction.

We also recommend Trading Suppliers and Manufacturers of 3-(4-chlorobenzyl)-1,3-benzothiazol-3-ium (cas 748088-78-0). Pls Click Website Link as below: cas 748088-78-0 suppliers

Prev:Synthesis of hybrid microspheres from zirconium butoxide and an ionic–non-ionic copolymer
Next:Synthesis, crystal structure and magnetic property of a new 1D molecular material [1-(4′-chlorobenzyl)–4-aminopyridinium](+) bis(maleonitriledithiolato)nickel(–))