Copper catalyzed direct aerobic double-oxidative cross-dehydrogenative coupling of imidazoheterocycles with aryl acetaldehydes: an articulate approach for dicarbonylation at C-3 position

Add time:07/16/2019    Source:sciencedirect.com

Direct aerobic oxidative cross-dehydrogenative coupling of aryl acetaldehydes at C-3 position of imidazoheterocycles via copper catalyzed reaction resulted in the synthesis of dicarbonylated imidazoheterocycles in 55–85% yields. The methodology provides a straightforward, high yielding and one-pot approach towards the synthesis of C-3 dicarbonylated imidazoheterocycles without prior activation of C(sp2)-H or a base. This also reports the first method of coupling of aryl acetaldehydes on imidazo[1,2-a]pyridine system via double-oxidative cross-dehydogenative process.

We also recommend Trading Suppliers and Manufacturers of (3-BROMOPHENYL)ACETALDEHYDE (cas 109347-40-2). Pls Click Website Link as below: cas 109347-40-2 suppliers

Prev:Highly efficient Michael-type addition of acetaldehyde to β-nitrostyrenes by whole resting cells of Escherichia coli expressing 4-oxalocrotonate tautomerase
Next:Organocatalytic asymmetric cross-aldol reaction of 2-chloroethoxy acetaldehyde: diversity-oriented synthesis of chiral substituted 1,4-dioxanes and morpholines)