The structure-carcinogenicity relationship among derivatives of 4-nitro and 4-hydroxylaminoquinoline 1-oxides

Add time:07/18/2019    Source:sciencedirect.com

Mice were examined for carcinogenic effects of 4-nitro and 4-hydroxylamino-quinoline 1-oxide derivatives which were substituted by an additional group or atom such as a methyl-, halogeno- or nitro-group. It became evident from the carcinogenicity-structure relationship that carcinogenesis of this class of compounds requires the presence of a nitro group at position-4 and an oxide group at position-1 of the quinoline nucleus. However, the proximate structure in the carcinogenic action must be the 4-hydroxylaminoquinoline 1-oxide structure which is formed from the 4-nitro derivatives by metabolic reduction.

We also recommend Trading Suppliers and Manufacturers of 4,6-Dinitroquinoline 1-oxide (cas 1596-52-7). Pls Click Website Link as below: cas 1596-52-7 suppliers

Prev:Properties of 4-(1′-n-tridecyl)pyridine N-oxide in the extraction and polymer inclusion membrane transport of Cr(VI)
Next:The reversible deactivation of β-lactamase from Staphylococcus aureus by quinacillin (cas 1596-63-0) and cephaloridine and its modification by antibodies)