Structure—Activity Relationship Study of Anthraquinones: 1 ,4-Dihydroxy-5,8-bis[[2-(2-hydroxyethoxy)ethyl]amino]-9,10-anthracenedione, an Analog of an Established Antineoplastic Agent

Add time:07/18/2019    Source:sciencedirect.com

An oxygen analog of the antineoplastic anthraquinone, 1,4-dihydroxy-5,8-bis[[2-(2-hydroxyethyl)amino]ethyl]arnino - 9,10 -an-thracenedione, was synthesized. This compound, 1,4-dihydroxy-5,8-bis[[2-(2-hydroxyethoxy)ethyl]amino]-9,10-anthracenedione, was found to be inactive against P-388 lymphocytic leukemia. A comparative structure-activity study of these two anthraquinones in terms of previously postulated N—O—O triangulation hypothesis was discussed.

We also recommend Trading Suppliers and Manufacturers of 1,4-Bis(2-Hydroxyethoxy)-2-Butyne (cas 1605-85-5). Pls Click Website Link as below: cas 1605-85-5 suppliers

Prev:Synthesis and characterization of bright green terbium coordination complex derived from 1,4-bis(carbonylmethyl)terephthalate: Structure and luminescence properties
Next:Optimization of the high-performance liquid chromatographic separation of a complex mixture containing urinary steroids, boldenone and Bolasterone (cas 1605-89-6): application to urine samples)