Synthesis, biochemical activity and behavioral effects of a series of 1,4,5,6-TETRAHYDROPYRIMIDINE (cas 1606-49-1)s as novel ligands for M1 receptors

Add time:07/19/2019    Source:sciencedirect.com

A series of novel tetrahydropyrimidines was synthesized and examined for M1 muscarinic receptor activity. 1,4,5,6-Tetrahydro-5-methoxycarbonyl-pyrimidine hydrobromide (1a; CDD-0034-C) displayed a high affinity for muscarinic receptors in rat brain and stimulated PI metabolism in rat hippocampus. Compound 1a ameliorated memory deficits associated with lesions of the septohippocampal cholinergic system in rats.

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