Stimulus properties of some analogues of 4-methylaminorex

Add time:07/19/2019    Source:sciencedirect.com

The stimulus properties of aminorex and analogues of 4-methylaminorex, namely (4S,5S)-4-methylaminorex, N-methyl-(4S,5S)-4-methylaminorex, and the regioisomeric (R)-and (S)-2-amino-4-phenyl-2-oxazoline (rexamino) were compared in rats trained to distinguish (S)-amphetamine (1 mg/kg) from saline.The first three compounds, aminorex, (4S,5S)-4-methylaminorex, and N-methyl-(4S,5S)-4-methylaminorex shared discriminative stimulus effects with amphetamine, although the stimulus properties for racemic aminorex were less than those of the other two compounds. The two regioisomers, (R)-and (S)-rexamino, produced only partial generalisation to the amphetamine.

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