Quinazoline-directed selective ortho-iodination for the synthesis of 2-(2-iodoaryl)-4-arylquinazolines

Add time:07/18/2019    Source:sciencedirect.com

Palladium-catalyzed ortho-iodination of 2, 4-diarylquinazolines via C-H activation is described. These palladium catalytic quinazoline-directed mono-iodination reactions are very efficient, highly selective and with a broad substrate scope, producing the corresponding 2-(2-iodoaryl)-4-arylquinazolines with good yields.

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