Inhibitory effect of human recombinant interleukin-1 α and β on growth of human vascular endothelial cells

Add time:07/17/2019    Source:sciencedirect.com

Endothelial cell growth factor(ECGF) is a potent polypeptyde mitogen which stimulates the growth of endothelial cells. The mitogenic effect of ECGF was inhibited by addition of recombinant interleukin-1 (rIL-1) α or β in a concentration dependent manner. The morphological change was not observed distinctly. In the condition without ECGF, both types of rIL-1 enhanced [3H] -thymidine uptake slightly, but failed to increase cell numbers. These data suggest the possibility that the effect of rIL-1 on EC is modulated by the presence of ECGF.

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