Dyfonate metabolism studies

Add time:07/19/2019    Source:sciencedirect.com

Dyfonate (O-ethyl S-phenyl ethylphosphonodithioate) is rapidly metabolized in living rats to form polar products which are excreted in the urine and in the feces via the bile. The identified metabolites account for more than 94% and 78% of the administered dose from both the phosphorus- and thiophenol-containing moieties, respectively. The metabolic pathway found for Dyfonate in rats is similar to that previously established in plants. The terminal residues are O-ethyl ethane phosphonothioic and -phosphonic acids, and O-conjugates of 3- and 4-(hydroxyphenyl) methyl sulfone. Dyfonate-oxon is the intermediate in formation of O-ethyl ethane phosphonic acid, as the phosphonothioic acid is not desulfurated in vivo. The oxon is formed in the rat liver microsome-NADPH2 system, but in vivo, it appears to undergo rapid hydrolysis.

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