2-(1H-Pyrazol-1-yl)acetic acids as chemoattractant receptor-homologous molecule expressed on Th2 lymphocytes (CRTh2) antagonists

Add time:07/11/2019    Source:sciencedirect.com

In this manuscript, the synthesis and biological activity of a series of pyrazole acetic acid derivatives as CRTh2 antagonists is presented. Biological evaluation in vitro revealed that the pyrazole core showed in several cases a different structure–activity relationship (SAR) to that of related indole acetic acid. A potent series of ortho-sulfonyl benzyl substituents was found, from which compounds 27 and 63 were advanced to in vivo profiling.

We also recommend Trading Suppliers and Manufacturers of (R)-2-(Morpholin-2-yl)acetic acid hydrochloride (cas 1588480-38-9). Pls Click Website Link as below: cas 1588480-38-9 suppliers

Prev:Flotation and electrochemical behaviors of chalcopyrite and pyrite in the presence of N-propyl-N′-ethoxycarbonyl thiourea
Next:An orthogonal protection strategy for the synthesis of 2-substituted piperazines)