Iron-catalyzed regioselective cyclotrimerization of alkynes to benzenes

Add time:07/18/2019    Source:sciencedirect.com

We report the synthesis and characterization of simple di(aminomethyl)pyridine ligated iron-pincer complexes, which catalyzed the regioselective [2+2+2] cyclotrimerization of terminal aryl and alkyl alkynes to provide the 1,2,4-trisubstituted benzene molecules. Interestingly, internal alkynes also exhibited similar cyclization and resulted in hexa-substituted benzene compounds. Increased steric bulk on pincer ligands diminished the selectivity for cycloaddition. Cyclotrimerization reactions proceeded at room temperature upon activation of catalyst by a Grignard reagent. EPR studies indicated thermally induced spin crossover effect in catalyst.

We also recommend Trading Suppliers and Manufacturers of 4-(Allyloxy)-1-bromo-2-(trifluoromethyl)benzene (cas 1208-41-9). Pls Click Website Link as below: cas 1208-41-9 suppliers

Prev:Investigation on the cytotoxic effects of nitrogen-mustard-derived Schiff bases. Studies on the reactivity of the N-mustard pharmacophoric group
Next:Modification of the electronic properties of the π-spacer of chromophores linked to calix[4]arene platform for DSSCs applications)