Promoting effect of testosterone propionate on experimental exocrine pancreatic tumors by 4-hydroxyaminoquinoline 1-oxide in rats
-
Add time:07/18/2019 Source:sciencedirect.com
A single intravenous injection of 4-hydroxyaminoquinoline 1-oxide (HAQO) in a dose of 9 mg/kg induced exocrine adenomas of the pancreas in a significantly higher rate in male rats than in female rats. Castration following HAQO administration diminished the incidence of the pancreatic tumors in male rats. A combined treatment with castration and weekly injections of testosterone propionate in a dose of 1 mg/rat after HAQO administration resulted in high incidence of the pancreatic tumors in both sexes. From these findings, it is concluded that testosterone can promote the induction of the pancreatic tumors in rats by HAQO.
We also recommend Trading Suppliers and Manufacturers of 4-HYDROXYAMINOQUINOLINE N-OXIDE HYDROCHLORIDE (cas 1010-61-3). Pls Click Website Link as below: cas 1010-61-3 suppliers
Prev:Highly efficient yellow nondoped thermally activated delayed fluorescence OLEDs by utilizing energy transfer between dual conformations based on phenothiazine derivatives
Next:1-acetoxy-4-hydroxyimino-1,4-dihydroquinoline, a reactive intermediate derived from the potent carcinogen 4-nitroquinoline N-oxide) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- Reduced Pyridine nucleotide-dependent N-hydroxy amine oxidase and reductase activities of hepatic microsomes07/20/2019
- Identification of 4-acetoxyaminoquinoline from the hydrolysis of 1-acetoxy-4-acetoxyimino-1,4-dihydroquinoline, in vitro and in vivo properties07/21/2019
- 1-acetoxy-4-hydroxyimino-1,4-dihydroquinoline, a reactive intermediate derived from the potent carcinogen 4-nitroquinoline N-oxide07/19/2019
