Welcome to LookChem.com Sign In|Join Free

CAS

  • or
3-(3-Fluoro-phenoxy)-propionic acid, also known as fluoro-phenoxy-propionic acid, is a chemical compound with the formula C9H8O3F. It is a colorless to pale yellow crystalline powder that is sparingly soluble in water and soluble in organic solvents. 3-(3-FLUORO-PHENOXY)-PROPIONIC ACID features a fluorine atom attached to a phenyl ring connected to a propionic acid moiety, which makes it a versatile building block for the synthesis of various pharmaceuticals, agrochemicals, and other fine chemicals. Its unique structure contributes to its potential applications in the development of new drugs and biologically active compounds, as well as its studied potential as an antifungal and antimicrobial agent.

133077-42-6 Suppliers

Post Buying Request

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier
  • 133077-42-6 Structure
  • Basic information

    1. Product Name: 3-(3-FLUORO-PHENOXY)-PROPIONIC ACID
    2. Synonyms: 3-(3-FLUORO-PHENOXY)-PROPIONIC ACID;AKOS BB659;AKOS BBV-009270
    3. CAS NO:133077-42-6
    4. Molecular Formula: C9H9FO3
    5. Molecular Weight: 184.16
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 133077-42-6.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 262.202°C at 760 mmHg
    3. Flash Point: 112.376°C
    4. Appearance: /
    5. Density: 1.268g/cm3
    6. Vapor Pressure: 0.006mmHg at 25°C
    7. Refractive Index: 1.514
    8. Storage Temp.: Sealed in dry,Room Temperature
    9. Solubility: N/A
    10. PKA: 4.17±0.10(Predicted)
    11. CAS DataBase Reference: 3-(3-FLUORO-PHENOXY)-PROPIONIC ACID(CAS DataBase Reference)
    12. NIST Chemistry Reference: 3-(3-FLUORO-PHENOXY)-PROPIONIC ACID(133077-42-6)
    13. EPA Substance Registry System: 3-(3-FLUORO-PHENOXY)-PROPIONIC ACID(133077-42-6)
  • Safety Data

    1. Hazard Codes: Xi
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: IRRITANT
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 133077-42-6(Hazardous Substances Data)

133077-42-6 Usage

Uses

Used in Pharmaceutical Industry:
3-(3-FLUORO-PHENOXY)-PROPIONIC ACID is used as a building block for the synthesis of various pharmaceuticals, contributing to the development of new drugs and biologically active compounds due to its unique structure and properties.
Used in Agrochemical Industry:
3-(3-FLUORO-PHENOXY)-PROPIONIC ACID is used as a key intermediate in the production of agrochemicals, aiding in the creation of effective pesticides and other agricultural chemicals.
Used in Fine Chemicals Industry:
3-(3-FLUORO-PHENOXY)-PROPIONIC ACID is utilized as a component in the synthesis of fine chemicals, which are high-purity chemicals used in various applications, including research, pharmaceuticals, and specialty industries.
Used as an Antifungal Agent:
3-(3-FLUORO-PHENOXY)-PROPIONIC ACID is studied for its potential as an antifungal agent, indicating its use in combating fungal infections and contributing to the development of new antifungal medications.
Used as an Antimicrobial Agent:
3-(3-FLUORO-PHENOXY)-PROPIONIC ACID is also being investigated for its antimicrobial properties, suggesting its potential use in the development of new antimicrobial drugs to treat bacterial infections.

Check Digit Verification of cas no

The CAS Registry Mumber 133077-42-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,3,0,7 and 7 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 133077-42:
(8*1)+(7*3)+(6*3)+(5*0)+(4*7)+(3*7)+(2*4)+(1*2)=106
106 % 10 = 6
So 133077-42-6 is a valid CAS Registry Number.
InChI:InChI=1/C9H9FO3/c10-7-2-1-3-8(6-7)13-5-4-9(11)12/h1-3,6H,4-5H2,(H,11,12)

133077-42-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-(3-fluorophenoxy)propanoic acid

1.2 Other means of identification

Product number -
Other names 3-(3-Fluorophenoxy)propionic Acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:133077-42-6 SDS

133077-42-6Relevant articles and documents

Design, synthesis and biological evaluation of pyridyl substituted benzoxazepinones as potent and selective inhibitors of aldosterone synthase

Zhu, Haichao,Liu, Meihua,Li, Haiyan,Guan, Ting,Zhang, Qi,Chen, Yang,Liu, Yingxiang,Hartmann, Rolf R.,Yin, Lina,Hu, Qingzhong

supporting information, p. 2327 - 2332 (2021/04/12)

Exorbitant aldosterone is closely associated with various severe diseases, including congestive heart failure and chronic kidney disease. As aldosterone synthase is the pivotal enzyme in aldosterone biosynthesis, its inhibition constitutes a promising tre

Steroid synthase inhibitors and therapeutic application thereof

-

Paragraph 0066-0068, (2020/12/31)

The invention discloses a steroid synthase inhibitor and treatment application thereof, and belongs to the field of medicines. The compound capable of being used as the medicine has the effect of inhibiting steroid synthase, is high in inhibition rate and

Facile access to chiral 4-substituted chromanes through Rh-catalyzed asymmetric hydrogenation

Tao, Lin,Zhao, Qingyang,Zhang, Xumu,Dong, Xiu-Qin

, p. 1859 - 1862 (2020/01/21)

Rh/ZhaoPhos-catalyzed asymmetric hydrogenation of a series of (E)-2-(chroman-4-ylidene)acetates was successfully developed to prepare various chiral 4-substituted chromanes with high yields and excellent enantioselectivities (up to 99percent yield, 98percent ee). Moreover, the gram-scale hydrogenation could be performed well in the presence of 0.02 molpercent catalyst loading (TON = 5000), the hydrogenation product was easily converted to access other important compounds, which demonstrated the synthetic utility of this asymmetric catalytic methodology.

Exploiting the Chromone Scaffold for the Development of Inhibitors of Corticosteroid Biosynthesis

Gobbi, Silvia,Hu, Qingzhong,Zimmer, Christina,Engel, Matthias,Belluti, Federica,Rampa, Angela,Hartmann, Rolf W.,Bisi, Alessandra

, p. 2468 - 2477 (2016/04/10)

The inhibition of corticosteroid biosynthesis could be considered as an emerging strategy to reduce their abnormally high levels, and in this framework CYP11B1 and CYP11B2 represent the most promising targets. In continuing our studies on flavonoid-like scaffolds as privileged structures in medicinal chemistry, in this paper we describe a small library of pyridyl- and imidazolylmethylchromones as potential inhibitors of these enzymes. Testing results proved that position 3 of the chromone scaffold is the most favorable for the introduction of the heme-coordinating heterocycles and, among them, the 4-imidazolyl moiety is the most convenient for the interaction with the heme iron of the selected cytochromes. A low nanomolar inhibitor of CYP11B1 (5c) was obtained, endowed with reasonable selectivity toward CYP11B2 and able to better discriminate with respect to CYP17 and CYP19.

Synthesis, enantiomeric separation and docking studies of spiropiperidine analogues as ligands of the nociceptin/orphanin FQ receptor

Battisti, Umberto M.,Corrado, Sandra,Sorbi, Claudia,Cornia, Andrea,Tait, Annalisa,Malfacini, Davide,Cerlesi, Maria Camilla,Calò, Girolamo,Brasili, Livio

, p. 973 - 983 (2014/07/08)

A series of triazospirodecanone derivatives were synthesized as potential NOP ligands. 8-(Chroman-4-yl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one (4) and its 5-fluoro analogue (18) proved to be active as agonists with EC50 values in the submicromolar range. Single enantiomers of compound 4 were separated and tested as NOP agonists; the eutomer R-(+)-4 showed a pEC 50 of 7.34. Finally docking studies were performed on the NOP receptor to identify the most significant stereospecific interactions.

PHARMACEUTICALLY ACTIVE 6-N-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES

-

, (2009/01/24)

The invention provides compounds of the formula (0), in which the substituents and symbols are as defined in the description. The compounds inhibit the secretion of gastric acid.

CHROMAN DERIVATIVES AND THEIR USE AS 5-HT RECEPTOR LIGANDS

-

Page/Page column 30, (2008/06/13)

Compounds of the formula (I) or pharmaceutically acceptable salts thereof, wherein m, p, q, Ar, R1, R2, R3 and R4 are as defined herein. Also provided are methods for preparing, compositions comprising, and methods for using compounds of formula (I).

CHROMAN DERIVATIVES AND USES THEREOF IN THE TREATMENT OF CNS DISORDERS

-

Page/Page column 24, (2008/06/13)

Compounds of the formula (I): or pharmaceutically acceptable salts thereof, wherein m, p, q, Ar, R1, R2, R3 and R4 are as defined herein. Also provided are methods for preparing, compositions comprising, and met

BICYCLIC SUBSTITUTED INDOLE-DERIVATIVE STEROID HORMONE NUCLEAR RECEPTOR MODULATORS

-

Page/Page column 55, (2010/02/14)

The present invention provides a compound of the formula: Formula (I); or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising an effective amount of a compound of Formula I in combination with a suitable carrier, diluent, or excipient, and methods for treating physiological disorders, particularly congestive heart disease, hypertension, and atherosclerosis, comprising administering to a patient in thereof an effective amount of a compound of Formula I. X-16125

Quinoxaline compounds

-

Page/Page column 30, (2008/06/13)

Certain amidophenyl-sulfonylamino-quinoxaline compounds are CCK2 modulators useful in the treatment of CCK2 mediated diseases.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 133077-42-6