9-Fluorenylmethyl chloroformate (28920-43-6),9-Fluorenylmethyl chloroformate (28920-43-6) Manufacturers & Suppliers,Synthesis,MSDS

Basic information

Name:
9-Fluorenylmethyl chloroformate
CAS No.:
28920-43-6
Molecular Structure:
Formula:
C₁₅H₁₁ClO₂
Molecular Weight:
258.70 .
Synonyms:
Formicacid, chloro-, fluoren-9-ylmethyl ester (8CI);Fluorene-9-methanol,chloroformate (8CI);(9H-Fluoren-9-ylmethoxy)carbonyl chloride;9H-Fluoren-9-ylmethyl chloroformate;AminoTag;FMOC chloride;FmocCl;Fmoc-Cl;Carbonochloridic acid,9H-fluoren-9-ylmethyl ester;
EINECS:
249-313-6
Density:
1.288 g/cm³
Melting Point:
62-64 °C(lit.)
Boiling Point:
393.9 °C at 760 mmHg
Flash Point:
143.6 °C
Solubility:
dioxane: 0.1 g/mL, clear, colorless
Appearance:
white to off-white powder
Hazard Symbols:
C,T
Risk Codes:
34-20/21/22
Safety Description:
26-36/37/39-45-27 Details
Transport Information:
UN 3261 8/PG 2

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Chemistry

IUPAC Name: 9H-Fluoren-9-ylmethyl carbonochloridate
Molecular Formula: C₁₅H₁₁ClO₂
Molecular Weight: 258.70 g/mol
SMILES: C1(c2c(cccc2)c2c1cccc2)COC(=O)Cl
InChI: InChI=1/C15H11ClO2/c16-15(17)18-9-14-12-7-3-1-5-10(12)11-6-2-4-8-13(11)14/h1-8,14H,9H2
EINECS: 249-313-6
Classification Code: Indicators and reagents; Mutation data
Product Categories: Aromatic Esters; N-Protecting Reagents; Biochemistry; Fluorenes; Fluorenes & Fluorenones; Peptide Synthesis; Protection & Derivatization Reagents (for Synthesis); Protective Reagents (Peptide Synthesis); Synthetic Organic Chemistry; Fmoc-Amino acid series
Index of Refraction: 1.611
Molar Refractivity: 69.74 cm³
Molar Volume: 200.7 cm³
Polarizability: 27.64×10^-24cm³
Surface Tension: 50 dyne/cm
Density: 1.288 g/cm³
Flash Point: 143.6 °C
Enthalpy of Vaporization: 64.38 kJ/mol
Boiling Point: 393.9 °C at 760 mmHg
Melting Point: 62-64 °C(lit.)
Storage temperature: 2-8 °C
Solubility: dioxane: 0.1 g/mL, clear, colorless
Sensitive Moisture Sensitive
Vapour Pressure of 9-Fluorenylmethyl chloroformate (CAS NO.28920-43-6): 2.06E-06 mmHg at 25 °C

Uses

9-Fluorenylmethyl chloroformate (CAS NO.28920-43-6) is used for tagging silica-based derivatization reagents in HPLC. It is also used to introduce FMOC group as the FMOC carbamate.

Production

As can be expected, this compound may be prepared by reacting 9-fluorenylmethanol with phosgene:

Toxicity Data With Reference

mma-sat 100 µg/plate

MUREAV Mutation Research. 170 (1986),23.

Safety Profile

Hazard Codes: Corrosive C, Toxic T
Risk Statements: 34-20/21/22
R34:Causes burns.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 26-36/37/39-45-27
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S27:Take off immediately all contaminated clothing.
RIDADR: UN 3261 8/PG 2
WGK Germany: 3
RTECS: LQ6250000
F: 10-21
HazardClass: 6.1
PackingGroup of 9-Fluorenylmethyl chloroformate (CAS NO.28920-43-6): II

Standards and Recommendations

DOT Classification: 6.1; Label: Poison, Corrosive

Specification

9-Fluorenylmethyl chloroformate (CAS NO.28920-43-6), its Synonyms are 1-(9-Fluorenyl)methyl chloroformate ; Carbonochloridic acid, 9H-fluoren-9-ylmethyl ester ; 9H-Fluoren-9-ylmethyl chloroformate ; Fluoren-9-ylmethyl chloroformate ; Formic acid, chloro-, fluoren-9-ylmethyl ester . It is white to off white crystalline powder.