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L-Tryptophan

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Name

L-Tryptophan

EINECS 200-795-6
CAS No. 73-22-3 Density 1.363 g/cm3
Solubility 11.4 g/L (25°C) in water Melting Point 289-290 °C (dec.)(lit.)
Formula C11H12N2O2 Boiling Point 447.908 °C at 760 mmHg
Molecular Weight 204.25 Flash Point 224.687 °C
Transport Information Appearance White to off-white crystalline powder
Safety 24/25-36/37/39-36-26 Risk Codes 33-40-62-41-37/38-36/37/38-22
Molecular Structure Molecular Structure of 73-22-3 (L-Tryptophan) Hazard Symbols IrritantXi
Synonyms

L(-)-Tryptophan;EH 121;l-alpha-Aminoindole-3-propionic acid;(S)-alpha-Amino-beta-(3-indolyl)-propionic acid;Sedanoct;L-Tryptophan (JP14);L-Trp;(S)-alpha-Amino-beta-indolepropionic acid;NCI-C01729;(S)-2-Amino-3-(3-indolyl)propionic acid;(-)-Tryptophan;(S)-alpha-Aminoindole-3-propionic acid;(2S)-2-azaniumyl-3-(1H-indol-3-yl)propanoate;Tryptophan, L-;2-Amino-3-indolylpropanoic acid;WV;Pacitron;Indole-3-alanine;1H-Indole-3-propanoic acid, alpha-amino-, (S)-;(S)-Tryptophan;Alanine, 3-indol-3-yl;L-(-)-Tryptophan;Triptofano [Spanish];3-Indol-3-ylalanine;Ardeytropin;L-alpha-Amino-3-indolepropionic acid;(S)-alpha-Amino-1H-indole-3-propanoic acid;Tryptophan (VAN);alpha-Amino-3-indolepropionic acid, L-;Tryptophanum [Latin];L-Alanine, 3-(1H-indol-3-yl)-;L-Tryptophan (9CI);

 

L-Tryptophan Consensus Reports

NCI Carcinogenesis Bioassay (feed); No Evidence: mouse, rat NCITR*    National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD 20014) No. NCI-CG-TR-71 ,1978. . Reported in EPA TSCA Inventory.

L-Tryptophan Specification

The L-Tryptophan, with the CAS registry number 73-22-3,is also known as L(-)-Tryptophan; (S)-2-Amino-3-(1H-indol-3-yl)propanoic acid. It belongs to the product categories of Amino Acids;Amino Acids & Derivatives. This chemical's molecular formula is C11H12N2O2 and molecular weight is 204.23.Its EINECS number is 200-795-6. What's more,Its systematic name is L-Tryptophan. It is a white to off-white crystalline powder which is stable,incompatible with strong acids, strong oxidizing agents.And it can be improvement nutrition and enhancement physique. It is also uses in the biochemistry research, and it is used as sedative in the medicine.

Physical properties about  L-Tryptophan are:
(1)ACD/LogP:  0.704; (2)# of Rule of 5 Violations:  0; (3)ACD/LogD (pH 5.5):  -1.80; (4)ACD/LogD (pH 7.4):  -1.80; (5)ACD/BCF (pH 5.5):  1.00; (6)ACD/BCF (pH 7.4):  1.00; (7)ACD/KOC (pH 5.5):  1.00; (8)ACD/KOC (pH 7.4):  1.00; (9)#H bond acceptors:  4; (10)#H bond donors:  4; (11)#Freely Rotating Bonds:  4; (12)Index of Refraction:  1.698; (13)Molar Refractivity:  57.769 cm3; (14)Molar Volume:  149.875 cm3; (15)Polarizability:  22.901×10-24 cm3 ; (16)Surface Tension:  71.1620025634766 dyne/cm; (17)Density:  1.363 g/cm3; (18)Flash Point:  224.687 °C; (19)Enthalpy of Vaporization:  74.437 kJ/mol; (20)Boiling Point:  447.908 °C at 760 mmHg; (21)Vapour Pressure:  0 mmHg at 25°C.

You could convert the following datas into the molecular structure:
(1)SMILES:c1ccc2c(c1)c(c[nH]2)C[C@@H](C(=O)O)N;
(2)Std. InChI:InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1;
(3)Std. InChIKey:QIVBCDIJIAJPQS-VIFPVBQESA-N.

The toxicity data of  L-Tryptophan are as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
bird - domestic LD50 intraperitoneal 2410mg/kg (2410mg/kg)   Drugs in Japan Vol. -, Pg. 744, 1990.
man TDLo oral 300mg/kg (300mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: ANTIANXIETY
British Medical Journal. Vol. 2, Pg. 701, 1976.
man TDLo oral 857mg/kg/30D- (857mg/kg) BLOOD: EOSINOPHILIA

SKIN AND APPENDAGES (SKIN): OTHER GLANDS: OTHER

MUSCULOSKELETAL: OTHER CHANGES
New England Journal of Medicine. Vol. 322, Pg. 874, 1990.
mouse LD50 intraperitoneal 4800mg/kg (4800mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: CYANOSIS
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 11, Pg. 635, 1980.
mouse LDLo oral 15gm/kg (15000mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

LUNGS, THORAX, OR RESPIRATION: CYANOSIS
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 11, Pg. 635, 1980.
rat LD50 intraperitoneal 1634mg/kg (1634mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA Archives of Biochemistry and Biophysics. Vol. 58, Pg. 253, 1955.
rat LD50 oral > 16gm/kg (16000mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: COMA
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 11, Pg. 635, 1980.
rat LDLo unreported 2553mg/kg (2553mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 23, Pg. 884, 1973.
women TDLo oral 2700mg/kg/13W (2700mg/kg) LUNGS, THORAX, OR RESPIRATION: STRUCTURAL OR FUNCTIONAL CHANGE IN TRACHEA OR BRONCHI

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

BLOOD: EOSINOPHILIA
Annals of Internal Medicine. Vol. 112, Pg. 301, 1990.
women TDLo oral 3276mg/kg/9W- (3276mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

BLOOD: EOSINOPHILIA

SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
Annals of Internal Medicine. Vol. 112, Pg. 344, 1990.
women TDLo oral 4800mg/kg/34W (4800mg/kg) PERIPHERAL NERVE AND SENSATION: PARESTHESIS

SKIN AND APPENDAGES (SKIN): OTHER GLANDS: OTHER

BLOOD: EOSINOPHILIA
New England Journal of Medicine. Vol. 322, Pg. 874, 1990.
women TDLo oral 5400mg/kg/134 (5400mg/kg) BLOOD: EOSINOPHILIA

SKIN AND APPENDAGES (SKIN): OTHER GLANDS: OTHER
New England Journal of Medicine. Vol. 322, Pg. 874, 1990.
women TDLo oral 9gm/kg/22W-I (9000mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

LIVER: LIVER FUNCTION TESTS IMPAIRED

BLOOD: EOSINOPHILIA
Annals of Internal Medicine. Vol. 112, Pg. 957, 1990.
women TDLo oral 10960mg/kg/20 (10960mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA

BLOOD: EOSINOPHILIA
British Medical Journal. Vol. 301, Pg. 21, 1990.

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