Reference

Stabilized acrylates of polyvalent alcohols

Stabilized acrylates of polyvalent alcohols. Rosenkranz, Hans J.; Rudolph, Hans; Apel, Gerhard (Bayer A.-G., Ger.). Ger. Offen. DE 2527005 13 Jan 1977, 16 pp. (German). (Germany). CODEN: GWXXBX. CLASS: IC: C07C069-54. APPLICATION: DE 75-2527005 18 Jun 1975. DOCUMENT TYPE: Patent CA Section: 36 (Plastics Manufacture and Processing) Compds. of general structure PhCR:CHR1 (I, R = H, Me, R1 = H, CO2H, COCl, CH2OH, CHO) are used with phenols and hydroquinone as costabilizers for acrylates of polyols. Thus, trimethylolpropane [77-99-6] 402.5, acrylic acid [79-10-7] 648.5, p-methoxyphenol 0.53, and cinnamic alc. (I, R = H, R1 = CH2OH) [104-54-1] 5.23 g were mixed with 200 mL hexane, heated to reflux, mixed with 0.6 g concd. H2SO4 in 2 mL water, heated 100 h at 75.degree., freed of solvent at 40.degree. and 0.2 mm, neutralized, and filtered, giving a nearly colorless trimethylolpropane triacrylate [15625-89-5] with viscosity 20 s (DIN 53211 in a no. 4 cup at 20.degree.). In a control reaction without the cinnamic alc., the product began to gel before the reaction was complete, and was cloudy and gelled after 2 days storage at 60.degree.Except for chemicals metioned above, 102-92-1 and 1070-70-8 are also used.. .

Molecular structure-teratogenicity relationships of some fragrance additives

Molecular structure-teratogenicity relationships of some fragrance additives. Abramovici, Armand; Rachmuth-Roizman, Pepy (Sackler Sch. Med., Tel-Aviv Univ., Petah-Tiqva, Israel). Toxicology, 29(1-2), 143-56 (English) 1983. CODEN: TXCYAC. ISSN: 0300-483X. DOCUMENT TYPE: Journal CA Section: 62 (Essential Oils and Cosmetics) Section cross-reference(s): 4 Fragrance materials showed different teratogenic and lethal effects on young chick embryo, according to their mol. 106-24-1 and 19317-11-4 are cas registry numbers. These chemicals are also mentioned in this article. structure. For example, compds. with a CO group near an unsatd. C2 bond (except BzH [100-52-7]) induced a teratogenic effect at low concns.; the optimum teratogenic dose ranged from 0.5 mM/embryo for cinnamaldehyde [104-55-2] to 5.0 mM/embryo for farnesal [19317-11-4]. Hydroxycitronellal [107-75-5] was more embryotoxic than citronellal [106-23-0]. Also compds. with terminal alc. function, e.g., geraniol [106-24-1], nerol [106-25-2], cinnamyl alc. [104-54-1] and farnesol [4602-84-0], showed low teratogenic activity, as compared to their aldehydic derivs. The teratogenic effects of these compds. were organ-dependent, e.g., compds. with an a-carbonyl group were more teratogenic to the embryonic skeleton. .